The composition of this substance includes mucopolysaccharides with a high polymerization ability and consisting of equimolecular amounts of glycuronic acid and amino sugar. At the same time, collagen necrosis develops with a plasma cell reaction and hyperglobulinemia (collagen triad). Pathological disorders of connective tissue permeability also occur. So, as you can see, the physiological properties of connective tissue are under the control of the enzyme hyaluronidase, whose activity is reduced by hormones of the adrenal cortex. In allergic conditions (with exacerbation of rheumatism), as a result of enzymatic cleavage of the protein complex of mucopolysaccharide, the main intermediate substance, it is converted into an insoluble form. Stimulation of the adrenal cortex function causes a decrease in the activity of hyaluronidase in the body, resulting in the restoration of collagen-mucopolysaccharide complexes. This explains the beneficial effect of adrenocorticotropic hormone and cortisone in rheumatism. There are indications in the literature that the action of hyaluronidase with the destruction of hyaluronic acid may be important not only in the development of collagenization, but also in the reactivation of infection. Thus, the histochemical transformation in the main substance of the connective tissue, as a consequence of the introduction of infection, itself creates a favorable environment for the development of infection.

These histochemical changes in connective tissue can be long-lasting not only in the period of the so-called alternative exudative changes in rheumatism, but also in the proliferative stage of the disease, covering both rheumatic nodules and the surrounding tissue. It is necessary to abandon the strict differentiation of the stages of the rheumatic process from each other, as well as the position that the alterative-exudative stage lasts a short time. Judging by the clinical data (latent course of recurrent endocarditis), it can last for months and years, exacerbating the latent course and determining the lability of both the infectious and allergic process and hemodynamics in rheumatic endomyocarditis. In a pronounced form, the exudative phase of rheumatism occurs in the form of acute outbreaks and always gives a clear clinical symptom complex: arthritis, endo-, myopericarditis, serositis, etc. A larger bankroll means more opportunities to place winning bets without increasing your personal risk. That is why smart bettors always use 1xbet free promo code india during the sign-up process on 1xBet, regardless of their experience level. This action guarantees a 100% welcome bonus up to €130, matching your first deposit dollar for dollar. You can then spread your bets across multiple events, build accumulator bets with three or more selections, or try live betting with extra confidence.

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